Drawing on the American School of Comparative Literature, this study examines the representations of Satan, the creation myth, the Fall, and loneliness in Yeklia and Her Solitude by Mohammad-Taqi Modarresi and The Mysterious Stranger by Mark Twain. The central argument of the article is that, despite belonging to two distinct linguistic and cultural traditions, both authors displace Satan from his conventional role as the embodiment of absolute evil and temptation, recasting him instead as a cognitive, inquisitive, and revelatory figure. Through dialogue and dramatic exposition, this figure challenges the foundations of religious authority, institutional morality, social order, and simplistic narratives of sin. In Modarresi’s novel, Satan stands beside the ostracized Yeklia, exposing the suffering of women, the suppression of love, the violence of tradition, and humanity’s exile from meaning. In Twain’s work, Satan radically destabilizes the Church, superstition, collective morality, free will, and even the reality of the world itself. The study demonstrates that the Fall in these two novels is no longer merely a narrative of human disobedience and divine punishment; rather, it is transformed into a modern experience of departing from certainty, losing innocence, and confronting existential solitude. The findings further reveal that Modarresi, even amid darkness, preserves the possibility of tragic meaning, love, and human resistance, whereas Twain, through philosophical pessimism and dark irony, reduces even the possibility of meaning to the realm of dream and illusion.